Were you on Nardil? Did it just recently quit? Where have you been hiding all this time with such good news? And finally, please tell us you're not a "shill" or a "plant" from Big Pharma... this is a life or death situation... this reformulated Nardil is probably responsible for deaths!

Glad to have you aboard.
Very appreciative of any help you can give us.
Please, just tell us a bit about who you are. We are all just hanging on, and some of what you say appears to be a mirage in the distance... ?!? Thank you though!

Dan   (Thu Sep 2 19:01 2010)

Dear Luigi, thanks for your thoughtful
remarks. you are a right to be wary of the
"new kid on the block" namely myself, as the
pharmaceutical industry is notoriously
corrupt and often unaccountable. I
completely understand your concerns. I got
sick almost 4 months ago myself, albeit
possibly less impaired than many of the poor
souls in this forum. I myself have
experienced the disillusioning tolerance
effect to many drugs and food supplements
which made me initially function well. So I
could only feel compassion towards those
individuals on these boards and
www.askapatient.com many of who's lives were
transformed by the original Nardil formula
who "turned back into pumpkin" around 2003
when the rug was pulled from under their feet
with the neo-Nardil formulation. Thanks be to
God I am still well enough to offer my
professional support to you and them by doing
what I can to accelerate the process of
having this wonderful medicine made available
again to the general public. So people can
have their lives back. That's all, no other
agenda. I also have pharmaceutical contacts
there in England who are interested in
helping if they can in any way...I have some
really good news on that front, which I need
to confirm before I can post it to this
forum. So stay tuned and God bless you Luigi
for all your dedication and devotion in
leading your army of disaffected Nardil users
despite the bitter struggle you have had to
face. I have a feeling the worm is going to
turn for us all...    (Thu Sep 2 17:53 2010)

I do appreciate your imput and opinions-But
let me remind you we been here for years, the forum name its been changed 2 time, first one:NARDIL Probem Activism (from http://www.stratguitar.com)and we haslo moderator, we had over 1k active members- Now: Anxiety Commumity, only a handfull of member-
I Dr. Knafo for yers........ I under the impression that you are here to make a deal with Dr.H Knafo> Let me ask this question:HOW CAN YOU HELP ERFA?
I like to tell you ERFA is well prepared to remake the old Nardil, its need only the approval fro Health Canada
I an sure you are not in any position to solve this problem, if you can try to help UK......... we can solve the problem without you (maybe)
Have a nice day
Luigi   (Thu Sep 2 10:33 2010)

Dear Dr Knafo

I am a British pharmacologist writing to give
my professional support to the growing
international community of dissatisfied users
of the reformulated Nardil (Phenelzine
Sulphate Tablets, USP) product (Parke-Davis
Division of Pfizer Inc, 2003) which was
recently licensed to ERFA Canada Inc.

The consensus of this community is that the
reformulated product is grossly inferior to
the original Nardil product (Parke Davies
Division of Pfizer Inc, 2001), has a higher
incidence of adverse effects and, for many
users, has completely lost its potent
antidepressant and panicolytic properties.

From my point of view this tends to confirm
Pfizer's own internal in vitro post-marketing
QC studies which demonstrated efficacy issues
with the reformulated tablets.

It is my contention that this loss of
efficacy and increase in adverse effects is
owed to a change of inactive tablet
excipients in the two dosage forms.
Interestingly this is reflected in a change
in the pharmacokinetic properties between the
two formulae. Time taken to reach peak plasma
concentration is significantly shorter in the
reformulated tablet (43 minutes) as compared
with the original tablet (2-4 hrs) (Robinson
et al., 1985, as cited in Mallinger & Smith,
1991) which may indicate that the new tablets
are dissolving more rapidly in the stomach
and undergoing more first pass metabolism.
This seems to be echoed by some users who
report that the new tablets sometimes begin
to dissolve in the mouth if not immediately
ingested.

Of note is that the same efficacy and
toxicity issues have also been reported by
users of the reformulated Nardil product
licensed to Link Medical Products Pty Ltd,
2004 although I do not have any
pharmacokinetic data for these tablets to
hand.

The prevailing desire of the great many
(albeit under-represented) individuals
affected is that the original Nardil
formulation be re-instated and once again
made available to the general public.

We look forward to receiving your response

Kind Regards

Simon Galloway

(Consultant pharmacologist) for and on behalf
of Surescreen Diagnostics

1 Prime Parkway, Derby DE1 3QB (Tel +44 )
(0)1332 365318 (Fax+44(0)1332 292230 View
www.surescreen.com for Medical and
Healthcare, www.ssdlab.com for Laboratory
and Forensics, and www.alcometer.co.uk for
Alcohol testing.

=============================================

HOW TO BE FREE OF THE PAINS OF PURGATORY
HERE:-
http://www.catholicrevelations.org/Heaven.htm
   (Wed Sep 1 11:30 2010)

Sir
Soon after the reformulation I did call Pfizer (I was very sick), I did ask did you change some thing in the Nardil? the answer was: We changed for the better and i replay TO KILL ME? She answer back: That its what they told to me say....
Mr. Simon to me did mean:"Frankly,my dear,I DON'T GIVE A DAMN" about you complaint.
You mention that apparently Pfizer did owen study proving that the new formula is not good as effective as the original, and all this is been by them...... Liers does not work at ALL.
Further more I have a CD which clearly indicate that "Pifizer" never done a clinical test, an plus NO one new of the change: Doctors-Pharmacists-Psychiatrists- and US.......... If you trust Pfizer let me know please
Have a nice day Simon
Luigi   (Wed Sep 1 10:22 2010)

Hi - You are a Godsend.
I, for one, have tried 2 other delivery methods of Nardil, made by a compounded pharmacy: Liquid (syrup) and Troches.
Neither worked !
It was like getting zero phenelzine.

I recently read that 73% of Nardil is recovered in urine. Does that mean Nardil users get only 27% benefit?
True?
Thanks for joining the miserable Nardil Club :)
   (Tue Aug 31 20:23 2010)

I really hope they get this off the ground and fast. I am havng a rough time and could use that Original Nardil like NOW! ERFA has been hearing from Psychiatrists that Nardil doesn't work right. DUH!!! Pfizer knows it too. Just reformulate back to the Original.
We don't need no testing! Ship me some and I'll tell ya' how I feel! And Hurry!!!

Welcome aboard Simon

Dan

Dr. Henri Knafo
888-922-3133
henri.knafo@erfa.net

   (Mon Aug 30 18:27 2010)

Hello again guys. I was just on the phone to
Dr Henri Knafo of ERFA Pharmaceuticals Canada
concerning any progress they have made in
gaining approval from their Health Regulatory
Agency "Health Canada" to manufacture and
market the original Nardil formulation. He
tells me the agency is in the process of
reviewing the evidence ERFA have submitted
for the difference in product efficacy
(effectiveness) between the original Parke
Davies Nardil and the new Pfizer formulae.
Apparently Pfizer did their own studies
proving that their new formulation is not as
effective as the original and all of this has
been accepted by them. But Dr Knafo is not
certain this will be enough as these studies
were conducted in vitro (test tube) and non
in vivo (living systems). It may fall to ERFA
to present animal studies and/or human
volunteer trials to prove that this is the
case in living systems or it may not. Health
Canada may accept their in vitro data
rationale and grant a marketing authority for
the original formulation. Apparently all your
complaints are finding a voice, and
psychiatrists and other professionals are
providing the same post marketing feedback
about the Pfizer product to ERFA. Even Pfizer
France (at long last) are taking it all very
seriously. I asked if he would be recruiting
for a small placebo controlled human
volunteer cohort to test the original Nardil
against the new in the near future and he
said "quite possibly". I pointed out that
out of the estimated 80,000 public complaints
this would just be a slice of an inestimably
higher market which never made official
complaints about the drug since 2003. He
agreed and feels that there is definately a
good reason to proceed. He tells me they have
the capability for it right now (e.g. the
pharmaceutical process technology equiptment
etc)but that the financial costs will have to
be given the green light too. He has asked me
to put down a brief technical summary of your
thesis to him by email and wants to send it
to the president of EFRA as they are having a
meeting very soon. He will be in turn writing
back to me as soon as he hears back from
Health Canada. Personally, I think we should
get some positive press for this, something
like "ERFA Announces it is seeking marketing
authorisation for Original formula Nardil" or
such like. What do you think? I also intend
on asking him how suitable Phenelzine
sulphate BP would be for intramuscular and/or
intravenous administration...Hang in there
guys.   (Mon Aug 30 16:57 2010)

Sis
I didi use ENTERIC caples, best qualety=0
I did use Cavolin = 0
and more more resoults where 00
--------------------------------------------
I come to this coclusion, by using: Coscarmellose sodium, which its a potent dissolvant, this dissolve entric capsle in no time. Let try to remeber you this Croscarmellose Sodium whas not...... actually where ither exipients to make the Phenelzine Sulphate in slow time release.
I would like to know from you why in hell Pfizer put this Croscarmelose sodium in the new formula. The old formula was working good, now you suggest to use it by via Anal?
Lets ERFA remake the old formula and forget the via ANAL. I dont like to put in my ass
the phenelzine Sulphate...... Why this mary-
go around? THE OLD FORMULA ITS THERE AND LET USE IT
Have a nice day SIR
Luigi (Canada)   (Mon Aug 30 11:48 2010)

I am a British Pharmacologist who got sick
myself 4 months ago and have been taking a
quiet interest in the Nardil reformulation
fiasco...My knowledge of pharmacodynamics
(drug receptor physiology) is better than my
knowledge of pharmaceutics (drug dosage
design) and pharmcokinetics (absorption,
distribution and elimination of drugs) but I
am willing to have a stab at this. I was
wondering what success, if any, had been had
by board members here, with other dosage
forms and delivery methods. Am I right in
saying that both crushing the Neonardil into
enteric coated capsules And/OR coating the
existing tablets with Shellac or wax doesnt
work? If this is the case it would suggest
that it is not delivery to the small
intestine that is the problem but the
disintegration, disaggregation, dissolution,
dispersion and absorption of the tablet that
once it is there. Has anyone (Dr Undies?!)
been brave enough to attempt the rectal
administration of the modified tablets? The
other option is the intramuscular route like
diabetics do (I take my zinc supplement this
way because I don't absorb it well from the
bowel) but I would need to check on whether
the drug would be subject to metabolism in
muscle tissue for this first. Don't ever give
up guys. There are lots of ways around this.
We have access to 36 different suppliers for
the pharmaceutical grade Phenelzine sulphate
powder BP/USP, enteric capsules, other
pharmaceutical excipients. My contrator also
has a tablet press sitting there doing
nothing. Maybe I can convince him to apply
for a manufacturers licence with the MHRA to
re-manufacture the old Parke Davis form for a
trial batch. Anyway, just let me know what
has been tried, worked and failed so far and
I will see what I can do. Love and Prayers,
Simon   (Mon Aug 30 9:02 2010)

Dan
ERFA as the old formula, they are waiting the approval from Helth Canada; After the approval will take some time to replace the mixer machine> Once more i do hope the Health Canada will humanlly and let hope that so called Pfizer does not control or will debate it. Its my opinion that Pfizer should be sued for inaccurate ifomation in regard of the new (garbage)Nardil> Under the federal trade practices act, or the relevant State of Territory:Fair Trading Act. Penalties can be SEVERE: Unconsciable barganing which one party taking advange of the other party..... If was ERFA for sure i woould sue Pfizer under this Act
Have a nice day Dan
Luigi   (Mon Aug 30 6:30 2010)

Hi Luigi, I was just wondering if you might be able to tell us all a bit about what ERFA is trying to actually do with the Nardil on this go around? Can they actually make the Original... or do they have to try some version in between? You have had the most contact with Dr. Knafo of anyone here, and I do agree that he is indeed a nice and helpful man. Just wanted to know what you might be able to tell us --
Also, any input about "Health Canada" and how they function would be appreciated.

Thanks again Luigi.

Dan

Dr. Henri Knafo
888-922-3133
henri.knafo@erfa.net
   (Fri Aug 27 13:27 2010)

Yes that what is all about..... But will take
more then one......... Let hope we still










alive

Yes that what is all about, but will take more then one day... Let hope we still alive
Have a nice day Double





   (Tue Aug 24 12:27 2010)

That's what I thought before. If they get approval from Health Canada then they can go ahead with trying to make the old Nardil, right?

   (Mon Aug 23 17:02 2010)

Apparently you dint read what its going on!
ERFA is waiting for the approval of Helth Canada in order to go haed
Have a nice day   (Mon Aug 23 16:51 2010)

Your welcome. Maybe Dr. Undies would give it a try as well?!?   (Mon Aug 23 14:49 2010)

Thanks, Dan! I'll probably try contacting him myself a bit later on..

   (Mon Aug 23 14:43 2010)

erfa.net (Corporate)
Dr. Henri Knafo
888-922-3133

henri.knafo@erfa.net
(Individual)

When I spoke with Dr. Knafo, I got the impression that they knew exactly what we needed and were going to see if it was possible to produce it themselves, or, do it under license from Pfizer. They are looking at ways to create "Working" Nardil... and are being cautious about what they say and to whom.
   (Mon Aug 23 14:26 2010)

What the hell, then?? So if they can't make old Nardil at the risk of losing their license then what's with all this recent talk of them bringing it back?

   (Mon Aug 23 1:09 2010)

I did ask the very same question to Dr. Knafo, he did say if wee do that for sure wee will lose our licence
have a nice day Joe
Luigi   (Sun Aug 22 19:49 2010)

Hi Luigi, I think we need more people writing
letters. It's been a long 7 years on this crapdil,most people can't function well enough to even write a letter anymore.this is like a catch 22.Take depressed people
make them more depressed how can they fight back?Pfizer knew who to pick on when they took our real nardil away.I hope your people have enough guts to make a change.They could just make the real nardil and call it a generic,with the name phenelzine.They don't need pfizer.
Take care
Joe   (Sun Aug 22 14:15 2010)

Is this forum working?   (Sun Aug 22 8:18 2010)

This its my opinion,the other three company have not accepted the proposal to remake the "the old nardil", i'am sure that pfizer is'in control of these firms.
our hope remains that "health canada" is human to give the right to redo the old nardil to erfa
the possibility exist, unless pfizer also comtrols 'health canada"   (Sat Aug 21 13:42 2010)

I've had no other response from Dr Knafo since he sent the confirmation of receiving my email.

Cheers   (Fri Aug 20 8:06 2010)

Dr. Knafo has answered an e-mail today stating:
"We are waiting for analysis of our Department of Regulation and an approval of
Health Canada. We will keep you posted on our effort to satisfy both patients and physicians"

Did anyone else get this msg from Henri?

HelenK   (Mon Aug 16 20:05 2010)

Looks like ERFA Canada is going to try to make the "Original" Nardil... or at least something a lot more close than the current stuff. I haven't spoken with Dr. Knafo yet, but have emailed. He HAS spoken with Luigi.

I don't know the mechanics of drug approval in Canada; I do know that this is the first time anyone has proposed to try to make Old Nardil.

Dan   (Mon Aug 16 17:04 2010)

I remember it was during the mad-cow scare.
We stopped buying canadian beef. Canada was
at the point of screaming at the U.S.Then Pres.Bush went up on a friday.Came back on monday and said , we feel Canada's beef is safe so export will begain.And in the same breath said export of canadian drugs will be stopped because we can't trust drugs from other countries.Any fool can see how the drug companies set this up.What a scam.This shows the power drug companies have over the government.Their lobby gave more money than
the cattle lobby.But at the same time we were
still getting crapdil from France and med watch didn't even give us the time of day.
But NO drugs could come from Canada.So the poor seniors had to pay double for the same
meds.,eating cat food to survive,while drug companies fleeced their food money.Better in
Pig Pharma's pocket than in the mouths of old
seniors. Instead of singing ,God Bless America. We should be singing,God Help America.   (Mon Aug 16 13:03 2010)

Contact or Google 'Connection To Care.' Depending on your income (if it is not too high) you can get your Nardil for free from Pfizer.
Mine is free & every 2 months I pick up my 2 month supply from my Dr.'s office (90 mg/day). Applies to other meds as well. I get my Abilify for free also & that would be $400 per month. For different meds just find out who the manufacturer is & each has a program for free meds.    (Mon Aug 16 10:43 2010)

I just found a great website explaining drug sales from Canada.
Check it out:
www.suddenlysenior.com/canadiandrugstores.
html

Read the article:
IS BUYING IN CANADA LEGAL?

Apparently it IS legal.
They also list websites of many licensed
Canadian drug compaines that are
licensed and secure.
Their prices are clearly way cheaper than in
the US. (a big +)

Double, you were correct on this. They cannot stop you from buying Canadian.
But in past times, there was a law
prohibiting this practice because they
claimed Canadian drugs could not be trusted as pure and safe. HAH!
Tell Pfizer this!

   (Mon Aug 16 10:11 2010)

I hear ya. The FDA tries to control everything!
But I swear I remember hearing that it is against the law to buy drugs from Canada because the USA wants all the profits.
Therefore, Canada may not be able to sell to us (by law).
I'll bet Pfizer is behind this!
Think about it.

HelenK   (Mon Aug 16 9:45 2010)

Dear Helen
The FDA Can stop some one to remake the old Nardil in USA but does not have overview or power in Canada or other countrys, to prove it, this its an esempio gratia: Pfizer is making the new Nardil (garbage) in France...to void the
FDA and sale it in USA, does this clear what
you asked?
With your money you can buy any think from any where you like and that include medicinals, but you need a prescreption from you doctor, he can not tell you where to buy it.
In regard of letters to ERFA, if you know any one which does use the new Nardil or willing to buy it then will have a value.
Best regards and have nice day
Luigi    (Mon Aug 16 3:35 2010)

So I was curious, is anyone else taking some kind of compounded nardil right now or is it just me?

It works almost identically to the old nardil for me but it's expensive as heck, so bringing back the original would still help me out a lot if nothing else in terms of cost. The fact that insurance won't cover compounded medicine really doesn't help either.

   (Sun Aug 15 18:06 2010)

Oh fuck the FDA, there are still ways to get Canadian Nardil now as well as British Nardil even though we're technically not supposed to. For some of these methods, you still need a prescription but I imagine that's not even an issue for those of us posting here. As of right now the ERFA brand isn't much different than our current US crapdil, but if they end up bringing back the old one after all the FDA won't stand in our way to get it.

   (Sun Aug 15 17:58 2010)

It's good to get some news on Nardil.

I have a question: If they make it in Canada, those of us in the U.S. can't buy it. The FDA will not allow it.

ALSO: I sent a letter to Mr. Knafo. Should I send another one? I will do anything to help.

Helen K.   (Sun Aug 15 16:49 2010)

HELLO MY FRIENDS
________________
few days back I spoke to Dr. H. Knafo,we had long conversation. He did say ERFA as the old formula and the CEO he is aware of the need back of the old NARDIL.
ERFA will put a request to HEALTH CANADA to
remake the old Nardil, we did conclude 40 letters from us its ok, but maybe not a sufficient number to force or compel Health Canada to give ERFA the PROCEEDING. I beg you all to send more letters to ERFA at:
henri.knafo@erfa.net
____________________
ASAP Dr.H.Knafo will post here his view
Regards Luigi   (Sun Aug 15 14:58 2010)

Thanks for the reply, Yes, I sent a letter to Luigi and He sent it. I hope something good comes from all this.It would be nice to feel alive again instead of half dead. I don't know how they screwed up so bad with
this new nardil but it is nothing like the old one.We've been trying seven yrs. to be heard lets hope these people will listen.
Take care
Joe   (Sat Aug 14 23:55 2010)

I've heard nothing more Joe and I doubt any one else has up to now. Did you send a letter to Dr Knafo? I'll be sure to let the forum know if and when I do hear anything.

Cheers   (Sat Aug 14 6:57 2010)

Anyone hear anything about whats going on?
If we have to take this body damageing phenelzine at least the sh*t should work.
I'm getting tired of being a slug   (Thu Aug 12 11:23 2010)

Ok I believe U... as I thought that we'd put our differences behind us. I retract that remark...but U need to do a decent scan of ur computer. Malwarebytes is a very good free app that will find just about anything. Also Avast Home Anti-virus is a very good free program to prevent & find most nasties!   (Thu Aug 12 8:14 2010)

They were NOT intentional. Found malware on PC-mail was sent out by malware NOT me.   (Thu Aug 12 7:35 2010)

Your puerile and pathetic email virus sites that continue to plague my junk folder are really just so lame and just so YOU! Why don't you just GROW the FUCK UP... wanker!

   (Thu Aug 12 0:56 2010)

If you go to Wikipedia and type in pfizer
it has a lot of information. Also type in
Nardil.
True Glrizzz, all we know is when pfizer took over the production they destroyed
the only drug that bettered our lives.
Hopefully, the people in the meeting will
listen to us and fix the problem.   (Sun Aug 8 14:00 2010)

Guess like water over the dam, it doesn't really matter now except for the indication of effective excipients.   (Sun Aug 8 8:39 2010)

We don't really know for sure it was reformulated in 1994.Unless we can find proof
I wouldn't believe it . It may have been done on paper but never took effect until
Pfizer took control in 2003.   (Sat Aug 7 22:52 2010)

Excellent posting by Double regarding the 1994 composition of Nardil. Dr. Bob also theorized that to effectively compound new Nardil to a controlled release formula one might use Methyl Cellulose (Methocel) along with lactose and a small amount of alcohol. Magnesium Stearate may or may not be important as it's main function is to aid in flowability/lubrication when compounding.   (Thu Aug 5 7:09 2010)

I hear you. I know what you are saying. No you didn't miss anything. Details are scarce for a certain reason right now. I didn't mean to be cryptic. I need a short while to compose a decent response. Believe me, if I knew exactly what they were doing and it wouldn't compromise getting Nardil back, I'd post it immediately. I'm not crazy. Promise! Dan   (Thu Aug 5 6:12 2010)

re:
" It looks like they switched makers of the Phenelzine and I believe it's off just enough
to cause all these problems we are having. "

You know what? That would be really "funny" if after all these years of deliberation, trial and error experimenting and countless ideas of possible augmentation.. that the real answer turned out to be something just as simple as that. Merely switch to another maker of Phenelzine and BOOM! Nardil is back to its old working self. No such luck though for us, I'm afraid :(

   (Thu Aug 5 2:06 2010)

We never really got that many solid details about the meeting to begin with, though (unless I missed something?).

I mean, did Dr. Knafo ever make a clear statement himself about what the specific goal of this meeting was, and what some of the different possibilities of action would be as a result of the meeting? Everything explained to me so far just seems so cryptic and open-ended... If you could clarify on any of this I would appreciate it. Thanks.

   (Thu Aug 5 2:00 2010)

I know there is this sense of waiting to hear something. I will post what I know when I know it. I, too, am waiting to hear how this meeting went and what Dr. Knafo and ERFA have to say about our situation.

I am sure that Luigi will post something as well -- just as soon as he gets some news.

The waiting is very hard. Even after so many years.

Thanks all, Dan
   (Wed Aug 4 23:11 2010)

It looks like they switched makers of the Phenelzine and I believe it's off just enough
to cause all these problems we are having.   (Wed Aug 4 11:50 2010)